A metabolic side effect of niacin is increased uric acid, predisposing to which condition?

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Niacin can raise serum uric acid by reducing renal excretion of urate. This higher uric acid level can crystallize in joints and trigger gout, an inflammatory arthritis caused by monosodium urate crystals. In people who are predisposed or have reduced kidney function, this makes gout more likely. The other options aren’t directly tied to this uric acid increase: hypertension and arrhythmia aren’t typical consequences of niacin-induced hyperuricemia, and anemia isn’t related to this mechanism.