ApoB is used as a marker of what?

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Multiple Choice

ApoB is used as a marker of what?

ApoB is a marker of the number of atherogenic lipoprotein particles in circulation. Each atherogenic particle (VLDL, IDL, LDL, and chylomicron remnants) carries one molecule of ApoB (ApoB-100 on the liver-derived particles and ApoB-48 on chylomicrons). Because there’s one ApoB per particle, the ApoB concentration reflects particle count rather than the cholesterol content per particle. This makes ApoB a better indicator of atherogenic particle burden than simply measuring LDL-C, since two people can have similar LDL-C but different numbers of particles — and thus different cardiovascular risk. HDL particles carry ApoA, not ApoB, so ApoB does not reflect HDL.

ApoB is a marker of the number of atherogenic lipoprotein particles in circulation. Each atherogenic particle (VLDL, IDL, LDL, and chylomicron remnants) carries one molecule of ApoB (ApoB-100 on the liver-derived particles and ApoB-48 on chylomicrons). Because there’s one ApoB per particle, the ApoB concentration reflects particle count rather than the cholesterol content per particle. This makes ApoB a better indicator of atherogenic particle burden than simply measuring LDL-C, since two people can have similar LDL-C but different numbers of particles — and thus different cardiovascular risk. HDL particles carry ApoA, not ApoB, so ApoB does not reflect HDL.

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