Bempedoic acid inhibits which enzyme?

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Multiple Choice

Bempedoic acid inhibits which enzyme?

Bempedoic acid works by dampening hepatic cholesterol production upstream of where statins act. It inhibits ATP citrate lyase, the cytosolic enzyme that converts citrate to acetyl-CoA, the building block for cholesterol and fatty acid synthesis. With ACL inhibited, less acetyl-CoA enters the pathway, so hepatic cholesterol synthesis falls. The drop in hepatic cholesterol prompts upregulation of LDL receptors, increasing LDL clearance from the blood and lowering LDL-C levels. It is a prodrug activated in the liver by an enzyme, so its activity is largely hepatic and carries a lower risk of muscle-related side effects compared with statins. The other enzymes listed are not the targets: HMG-CoA reductase is the statin target; lipoprotein lipase helps hydrolyze triglycerides in circulating lipoproteins; fatty acid synthase makes fatty acids from acetyl-CoA and malonyl-CoA.

Bempedoic acid works by dampening hepatic cholesterol production upstream of where statins act. It inhibits ATP citrate lyase, the cytosolic enzyme that converts citrate to acetyl-CoA, the building block for cholesterol and fatty acid synthesis. With ACL inhibited, less acetyl-CoA enters the pathway, so hepatic cholesterol synthesis falls. The drop in hepatic cholesterol prompts upregulation of LDL receptors, increasing LDL clearance from the blood and lowering LDL-C levels. It is a prodrug activated in the liver by an enzyme, so its activity is largely hepatic and carries a lower risk of muscle-related side effects compared with statins. The other enzymes listed are not the targets: HMG-CoA reductase is the statin target; lipoprotein lipase helps hydrolyze triglycerides in circulating lipoproteins; fatty acid synthase makes fatty acids from acetyl-CoA and malonyl-CoA.

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