Fenofibrate reduces synthesis of which hepatic lipoprotein by decreasing lipogenesis?

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Multiple Choice

Fenofibrate reduces synthesis of which hepatic lipoprotein by decreasing lipogenesis?

Fenofibrate activates PPAR-alpha in the liver, which shifts metabolism toward increased fatty acid oxidation and away from triglyceride synthesis. VLDL is assembled in the liver using triglycerides and ApoB-100, so when hepatic lipogenesis (triglyceride production) decreases, there is less substrate available to form VLDL, leading to reduced VLDL synthesis and secretion. Fenofibrate also boosts lipoprotein lipase activity to clear TG-rich particles, reinforcing the drop in VLDL. Thus, the hepatic lipoprotein whose synthesis is reduced by decreased lipogenesis is VLDL.

Fenofibrate activates PPAR-alpha in the liver, which shifts metabolism toward increased fatty acid oxidation and away from triglyceride synthesis. VLDL is assembled in the liver using triglycerides and ApoB-100, so when hepatic lipogenesis (triglyceride production) decreases, there is less substrate available to form VLDL, leading to reduced VLDL synthesis and secretion. Fenofibrate also boosts lipoprotein lipase activity to clear TG-rich particles, reinforcing the drop in VLDL. Thus, the hepatic lipoprotein whose synthesis is reduced by decreased lipogenesis is VLDL.

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