In HoFH, plasma total cholesterol is typically greater than which threshold?

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Multiple Choice

In HoFH, plasma total cholesterol is typically greater than which threshold?

Homozygous familial hypercholesterolemia causes near-complete loss of LDL receptor function, so the body can’t clear LDL effectively from birth. Since total cholesterol is largely made up of LDL cholesterol, this leads to very high total cholesterol levels. The typical plasma total cholesterol in HoFH is greater than 500 mg/dL, with some patients sometimes reaching even higher values like 1000 mg/dL. However, the common threshold used to describe the usual magnitude in HoFH is above 500 mg/dL, making that the best answer. Lower thresholds (like 200 or 300 mg/dL) are more characteristic of other forms of hyperlipidemia, not the severe HoFH profile.

Homozygous familial hypercholesterolemia causes near-complete loss of LDL receptor function, so the body can’t clear LDL effectively from birth. Since total cholesterol is largely made up of LDL cholesterol, this leads to very high total cholesterol levels. The typical plasma total cholesterol in HoFH is greater than 500 mg/dL, with some patients sometimes reaching even higher values like 1000 mg/dL. However, the common threshold used to describe the usual magnitude in HoFH is above 500 mg/dL, making that the best answer. Lower thresholds (like 200 or 300 mg/dL) are more characteristic of other forms of hyperlipidemia, not the severe HoFH profile.

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