Omega-3 ethyl esters are contraindicated in patients with which condition?

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Omega-3 ethyl esters are derived from fish oil, so they can provoke hypersensitivity reactions in people with seafood allergies. Known hypersensitivity to shellfish is a contraindication because shellfish allergens can be present in or cross-react with fish-derived products. Allergy to pollen is unrelated to this medication, and kidney disease does not by itself stop use, though dosing and safety should always be reviewed with a clinician. So the safe and appropriate restriction is avoiding use in someone with a known shellfish allergy.