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Multiple Choice

What defines high-intensity statin therapy per ACC/AHA guidelines?

High-intensity statin therapy is defined by how much LDL-C reduction it is expected to achieve. ACC/AHA categorize statin regimens by intensity, with high-intensity therapy yielding an average LDL-C reduction of ≥50%. Doses that achieve this include atorvastatin 40–80 mg daily and rosuvastatin 20–40 mg daily. The other options mix lower expected reductions (e.g., ≥25%) or pair a non-high-intensity dose with a misleading target (e.g., pravastatin 40 mg), or imply a stepwise approach after failure, which isn’t how intensity is defined.

High-intensity statin therapy is defined by how much LDL-C reduction it is expected to achieve. ACC/AHA categorize statin regimens by intensity, with high-intensity therapy yielding an average LDL-C reduction of ≥50%. Doses that achieve this include atorvastatin 40–80 mg daily and rosuvastatin 20–40 mg daily. The other options mix lower expected reductions (e.g., ≥25%) or pair a non-high-intensity dose with a misleading target (e.g., pravastatin 40 mg), or imply a stepwise approach after failure, which isn’t how intensity is defined.