What is the mechanism of action of evinacumab?

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Multiple Choice

What is the mechanism of action of evinacumab?

Evinacumab works by inhibiting ANGPTL3. ANGPTL3 normally blocks lipoprotein lipase and hepatic lipase, so stopping ANGPTL3 releases that brake and increases the breakdown of triglyceride-rich lipoproteins. This leads to lower levels of triglycerides and LDL/non-HDL cholesterol, which is especially helpful in conditions like homozygous familial hypercholesterolemia where LDL receptor–mediated clearance is limited. It does not activate ANGPTL3, nor inhibit HMG-CoA reductase (that’s how statins work), nor inhibit PCSK9.

Evinacumab works by inhibiting ANGPTL3. ANGPTL3 normally blocks lipoprotein lipase and hepatic lipase, so stopping ANGPTL3 releases that brake and increases the breakdown of triglyceride-rich lipoproteins. This leads to lower levels of triglycerides and LDL/non-HDL cholesterol, which is especially helpful in conditions like homozygous familial hypercholesterolemia where LDL receptor–mediated clearance is limited. It does not activate ANGPTL3, nor inhibit HMG-CoA reductase (that’s how statins work), nor inhibit PCSK9.

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