Which mechanism explains how fibrates reduce triglycerides?

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Multiple Choice

Which mechanism explains how fibrates reduce triglycerides?

Fibrates lower triglycerides mainly by activating a nuclear receptor called PPAR-alpha, which ramps up the activity and production of lipoprotein lipase (LPL). With more LPL activity, triglyceride-rich particles like VLDL and chylomicrons are rapidly hydrolyzed and cleared from the bloodstream, reducing circulating triglycerides. Additionally, PPAR-alpha activation boosts fatty acid oxidation in the liver, which lowers VLDL production. This combination makes triglyceride reduction the primary effect of fibrates. Other mechanisms listed belong to different lipid drugs (for example, inhibiting intestinal cholesterol absorption is how ezetimibe works, PCSK9 activation would affect LDL receptor levels, and inhibiting HMG-CoA reductase is the action of statins).

Fibrates lower triglycerides mainly by activating a nuclear receptor called PPAR-alpha, which ramps up the activity and production of lipoprotein lipase (LPL). With more LPL activity, triglyceride-rich particles like VLDL and chylomicrons are rapidly hydrolyzed and cleared from the bloodstream, reducing circulating triglycerides. Additionally, PPAR-alpha activation boosts fatty acid oxidation in the liver, which lowers VLDL production. This combination makes triglyceride reduction the primary effect of fibrates.

Other mechanisms listed belong to different lipid drugs (for example, inhibiting intestinal cholesterol absorption is how ezetimibe works, PCSK9 activation would affect LDL receptor levels, and inhibiting HMG-CoA reductase is the action of statins).

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