Which of the following is a lipid effect of fenofibrate?

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Multiple Choice

Which of the following is a lipid effect of fenofibrate?

Fenofibrate, a fibrate, activates PPAR-alpha, which boosts lipoprotein lipase activity and decreases hepatic production of VLDL. This leads to lower triglyceride levels and, importantly, a modest increase in HDL cholesterol. LDL-C lowering is not a reliable or major effect of fenofibrate, and triglycerides are not unchanged or increased with this drug. So the lipid effect that best fits fenofibrate’s profile is a modest rise in HDL-C.

Fenofibrate, a fibrate, activates PPAR-alpha, which boosts lipoprotein lipase activity and decreases hepatic production of VLDL. This leads to lower triglyceride levels and, importantly, a modest increase in HDL cholesterol. LDL-C lowering is not a reliable or major effect of fenofibrate, and triglycerides are not unchanged or increased with this drug. So the lipid effect that best fits fenofibrate’s profile is a modest rise in HDL-C.

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