Which of the following is a known adverse effect associated with bempedoic acid?

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Multiple Choice

Which of the following is a known adverse effect associated with bempedoic acid?

Bempedoic acid is known to raise uric acid levels, which can lead to hyperuricemia and gout, and there have been reports of tendon injuries including tendon rupture. The drug’s LDL-C–lowering effect comes from inhibiting ATP citrate lyase in the liver, but the urate-related effects and tendon injury risk are separate safety signals acknowledged in its labeling. Severe hyponatremia and hyperkalemia are not typical adverse effects associated with this medication, so the combination of hyperuricemia, gout, and tendon rupture best reflects the drug’s recognized safety concerns.

Bempedoic acid is known to raise uric acid levels, which can lead to hyperuricemia and gout, and there have been reports of tendon injuries including tendon rupture. The drug’s LDL-C–lowering effect comes from inhibiting ATP citrate lyase in the liver, but the urate-related effects and tendon injury risk are separate safety signals acknowledged in its labeling. Severe hyponatremia and hyperkalemia are not typical adverse effects associated with this medication, so the combination of hyperuricemia, gout, and tendon rupture best reflects the drug’s recognized safety concerns.

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