Which statement about fenofibrate's effect on HDL-C is true?

Enhance your knowledge of antihyperlipidemics and lipid management. Study with multiple choice questions and detailed explanations. Ace your test!

Multiple Choice

Which statement about fenofibrate's effect on HDL-C is true?

The main concept here is how fenofibrate affects HDL cholesterol. Fenofibrate activates PPAR-α, which shifts lipid metabolism toward breaking down triglyceride-rich particles and boosting the production and remodeling of HDL. While its strongest and most consistent effect is a marked reduction in triglycerides, it also causes a modest rise in HDL-C by increasing the hepatic production of HDL apolipoproteins (ApoA-I and ApoA-II) and promoting HDL maturation. Because this HDL-C increase is typically small to moderate, it’s better described as modest rather than large. So the statement that fenofibrate modestly increases HDL-C best fits. It is not a dramatic rise, and it is not absent or decreasing HDL-C.

The main concept here is how fenofibrate affects HDL cholesterol. Fenofibrate activates PPAR-α, which shifts lipid metabolism toward breaking down triglyceride-rich particles and boosting the production and remodeling of HDL. While its strongest and most consistent effect is a marked reduction in triglycerides, it also causes a modest rise in HDL-C by increasing the hepatic production of HDL apolipoproteins (ApoA-I and ApoA-II) and promoting HDL maturation. Because this HDL-C increase is typically small to moderate, it’s better described as modest rather than large. So the statement that fenofibrate modestly increases HDL-C best fits. It is not a dramatic rise, and it is not absent or decreasing HDL-C.

More practice questions